TOM STRACHAN

Human Molecular Genetics is an established and class-proven textbook for upper-level undergraduates and graduate students which provides an authoritative and integrated approach to the molecular aspects of human genetics. While maintaining the hallmark features of previous editions, the Fourth Edition has been completely updated. It includes new Key Concepts at the beginning of each chapter and annotated further reading at the conclusion of each chapter, to help readers navigate the wealth of information in this subject.The text has been restructured so genomic technologies are integrated throughout, and next generation sequencing is included. Genetic testing, screening, approaches to therapy, personalized medicine, and disease models have been brought together in one section. Coverage of cell biology including stem cells and cell therapy, studying gene function and structure, comparative genomics, model organisms, noncoding RNAs and their functions, and epigenetics have all been expanded.

Genética Molecular Humana Andrew P. Read; Tom Strachan Esta obra realiza un estudio completo de la genética molecular humana, disciplina en rápida expansión. Está construido en torno a la explicación de la estructura, la funcion y la evolucion del genoma humano, tal como lo esta revelando el Proyecto Genoma Humano. Abarca desde las descripciones basicas sobre la estructura y funcion del DNA y de los cromosomas hasta el diagnostico molecular y la terapia genica. El lector encuentra material actualizado y completo de temas como clonacion, cartografiado, mutacion y enfermedad genetica. La organizacion del libro permite una rapida evaluacion del contenido y un facil acceso al material y esta diseñado para que los lectores se sientan atraidos por el texto: se incluyen figuras de gran calidad para reforzar puntos tratados en el texto y recuadros en color para resaltar conceptos importantes.

Following the completion of the Human Genome Project the content and organization of the third edition of Human Molecular Genetics (HMG) has been thoroughly revised. There are new chapters on cells and development and on functional genomics. The sections on complex diseases have been completely rewritten and reorganized, as has the chapter on Genome Projects. Other changes include a new section on molecular phylogenetics (Chapter 12) and the introduction of Ethics Boxes to discuss some of the implications of the new knowledge. Virtually every page has been revised and updated to take account of the stunning developments of the past four years since the publication of the last edition of Human Molecular Genetics.