eBooks de Divulgación científica, página 5 de 115

Frontiers in Clinical Drug Research - Anti-Cancer Agents is a book series intended for pharmaceutical scientists, postgraduate students and researchers seeking updated and critical information for developing clinical trials and devising research plans in anti-cancer research. Reviews in each volume are written by experts in medical oncology and clinical trials research and compile the latest information available on special topics of interest to oncology and pharmaceutical chemistry researchers. The eighth volume of the book features reviews on these topics: - Key data management elements in clinical trials for oncological therapeutics - Prospects for therapeutic targeting of microRNAs in brain tumors - Breast cancer vaccines: current status and future approach - Desmocollin-3 and cancer - MDM2-p53 antagonists under clinical evaluation: a promising cancer targeted therapy for cancer patients harbouring wild-type tp53 - Towards targeted therapy: anticancer agents targeting cell organelle mitochondria - Anticancer therapeutic strategies in gliomas: chemotherapy, immunotherapy, and molecularly targeted therapy in adults Audience: Pharmaceutical Scientists, Medicinal Chemists, Clinical Oncologists, Researchers in Pre-clinical studies and clinical trials

Frontiers in Clinical Drug Research - Anti-Cancer Agents is abook series intended for pharmaceutical scientists, postgraduate students andresearchers seeking updated and critical information for developing clinicaltrials and devising research plans in anti-cancer research. Reviews in eachvolume are written by experts in medical oncology and clinical trials researchand compile the latest information available on special topics of interest tooncology and pharmaceutical chemistry researchers. The sixth volume of the book features reviews on these topics: · Immunomodulating Agents in The Treatment ofAcute Myeloid Leukemia · Potential Natural Products for Prostate CancerManagement· Inhibition of Key Protein-Protein Interactions bySmall Molecules for Cancer Drug Design· Efficacy of Hepatic Arterial InfusionChemotherapy (HAIC) For Advanced Hepatocellular Carcinoma· Targeting Cancer Stem Cells: Implications inHealth and Disease

This book is a guide for researchers, academics and experimentalists who wish to explore density functional theory (DFT) on selected molecular systems. The salient features of the book include concise and complete coverage of DFT on biologically active molecules, a basic guide to DFT for beginners followed by its computational application using a powerful Gaussian program. Subsequently, discussions on synthetic compounds, amino acids, and natural products have been offered by the authors for the benefit of the reader. The book also features an exclusive chapter on the quantum theory of atoms in molecules and is supplemented by an appendix on the Gaussian output for methane. Key Features:· basic introduction of density functional theory· practical introduction to Gaussian program· interpretation of input and output files· explanation of calculated parameters· examples of several bioactive molecules (syenthetic and natural)· correlation between theory and experiments· exploration of the hydrogen bonds· appendix covering Gaussian outputs for methane· beginner friendly text· references at the end of each chapter DFT Based Studies on Bioactive Molecules is a suitable handbook for academics, students and researchers who are learning the basic biophysics and computational chemistry of bioactive molecules with reference to DFT models.

Biochemistry:Fundamentals and Bioenergetics presents information about the basic andapplied aspects of the chemistry of living organisms. The textbook covers the scopeand importance of biochemistry, the latest physical techniques to determine biomolecularstructure, detailed classification, structure and function of biomolecules suchas carbohydrates, lipids, amino acids, proteins, nucleic acids, vitamins,enzymes and hormones. Readers will also learn aboutprocesses central to energy metabolism including photosynthesis andrespiration, oxidative phosphorylation, DNA replication, transcription andtranslation, recombinant DNA technology. Key Features- logical approach to biochemistry with several examples- 10 organizedchapters on biochemistry fundamentals and metabolism- focus onbiomolecules and biochemical processes - referencesfor further reading Biochemistry:Fundamentals and Bioenergetics is a useful textbook for undergraduatestudents involved in courses in life sciences, biochemistry and other branchesof natural sciences.

Frontiers in Clinical Drug Research - CNS and Neurological Disorders is a book series that brings updated reviews to readers interested in advances in the development of pharmaceutical agents for the treatment of central nervous system (CNS) and other nerve disorders. The scope of the book series covers a range of topics including the medicinal chemistry, pharmacology, molecular biology and biochemistry of contemporary molecular targets involved in neurological and CNS disorders. Reviews presented in the series are mainly focused on clinical and therapeutic aspects of novel drugs intended for these targets. Frontiers in Clinical Drug Research - CNS and Neurological Disorders is a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critical information for developing clinical trials and devising research plans in the field of neurology. Volume 10 of the series continues to present novel information about new and interesting approaches to treat common neurological disorders, with a focus on neurodegeneration and pain medicine. The volume presents 7 detailed reviews in total. - Neurodegenerative disease: prevention and treatment through plant extracts therapy- Emerging novel approaches and recent advances in Parkinsons disease treatment and diagnosis- Neurotrophic factors to combat neurodegeneration- Neural bases of executive function in ADHD children as assessed using FNIRS- Modulation of mesenchymal stem cells, glial cells and the immune system by oligodeoxynucleotides as a novel multi-target therapeutic approach against chronic pain- Chronic pain: focus on anticonvulsants- A review of the impact of testosterone on brain and aging-related decline in brain behavioural function

Frontiers in Clinical Drug Research Anti infectives is a book series that brings updated reviews to readers interested in learning about advances in the development of pharmaceutical agents for the treatment of infectious diseases. The scope of the book series covers a range of topics including the chemistry, pharmacology, molecular biology and biochemistry of natural and synthetic drugs employed in the treatment of infectious diseases. Reviews in this series also include research on multi drug resistance and pre-clinical / clinical findings on novel antibiotics, vaccines, antifungal agents and antitubercular agents. Frontiers in Clinical Drug Research Anti infectives is a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critically important information for developing clinical trials and devising research plans in the field of anti infective drug discovery and epidemiology. The seventh volume of this series features these interesting reviews:- Nucleic acid and peptide aptamers as potential antiviral drugs- Host-directed, antibiotic-adjuvant combination, and antibiotic-antibiotic combination for treating multidrug-resistant (mdr) gram-negative pathogens- Bioactive substances as anti-infective strategies against clostridioides difficile- Anti-toxoplasma drug discovery and natural products: a brief overview- Development of antimalarial and antileishmanial drugs from amazonian biodiversity

Advances in Organic Synthesis is a book series devoted to the latest advances in synthetic approaches towards challenging structures. The series presents comprehensive reviews written by eminent authorities on different synthetic approaches to selected target molecules and new methods developed to achieve specific synthetic transformations or optimal product yields. Advances in Organic Synthesis is essential for all organic chemists in academia and the industry who wish to keep abreast of rapid and important developments in the field. Contents of this volume include these 6 reviews: - Multicomponent synthesis of heterocycles by microwave irradiation- Stereoselective procedures for the synthesis of olefines- Advanced microwave assisted organic synthesis method in organic chemistry- Five and six-membered n-heterocycle rings from diaminomaleonitrile- Peptidomimetics: current and future perspectives on hiv protease inhibitors- A review on synthesis, chemistry, and medicinal properties of benzothiazines and their related scaffolds

Waste management is one of the major challenges for environmental and public health organizations for maintaining safety standards in any area. Population growth and urbanization increase the difficulty in maintaining a sustainable waste management system. Bioremediation refers to the use of living organisms in processes designed to remove toxic chemicals present in waste material. Bioremediation represents a sustainable way to remove a range of environmental pollutants. Bioremediation: Challenges and Advancements covers the subject of bioremediation in eight chapters that focus on a broad range of waste sources, their adverse impacts on the ecosystem, and the advanced strategies for their remediation. Each chapter also highlights the problems encountered in bioremediation processes. Key features: - Comprehensive coverage of bioremediation in 8 reader-friendly chapters - Highlights methods and challenges of bioremediation in one volume. - Introduces the reader to bioremediation - Explains recent biotechnological methods for removing heavy metals and xenobiotic compounds - Describes strategies including physical, chemical, and biological methods to mitigate radioactive waste from contaminated sites and water bodies - Details the use of microbial-aided remediation techniques for the management of biomedical and electronic wastes, and its impact on the ecosystem - Describes bioremediation technologies for decontamination of solid waste pollutants - Showcases the application of Omics approaches such as genomics, transcriptomics, proteomics, and metabolomics to improve bioremediation processes. - Covers bioremediation of agro-wastes - Includes detailed references This book is an informative reference for scholars (researchers, undergraduate and graduate students of environmental sciences, microbiology and biotechnology) professionals (environmental engineers) and researchers, giving each a good understanding of the significance of bioremediation in solid waste management and the restoration of contaminated sites.

The development of a vector for the delivery of therapeutic drugs in a controlled and targeted fashion is still a major challenge in the treatment of many diseases. The conventional application of drugs may lead to many limitations including poor distribution, limited effectiveness, lack of selectivity and dose dependent toxicity. An efficient drug delivery system can address these problems. Recent nanotechnology advancements in the biomedical field have the potential to meet these challenges in developing drug delivery systems. Nanomaterials are changing the biomedical platform in terms of disease diagnosis, treatment and prevention. Nanomaterials aided drug delivery provides an advantage by enhancing aqueous solubility that leads to improved bioavailability, increased resistance time in the body, decreased side effects by targeting drugs to the specific location, reduced dose dependent toxicity and protection of drugs from early release. In this two-part book, the contributors have compiled reports of recent studies illustrating the promising nanomaterials that can work as drug carriers which can navigate conventional physiological barriers. A detailed account of several types of nanomaterials including polymeric nanoparticles, liposomes, dendrimers, micelles, carbon nanomaterials, magnetic nanoparticles, solid lipid-based nanoparticles, silica nanomaterials and hydrogels for drug delivery is provided in separate chapters. The contributors also present a discussion on clinical aspects of ongoing research with insights towards future prospects of specific nanotechnologies. Part II covers the following topics: · Solid lipid nanoparticles and nanostructured lipid carriers · Silica based nanomaterials · Hydrogels · Metallic nanoparticles · Computational and experimental binding interactions of drug and ?-cyclodextrin · Clinical milestones in nanotherapeutics · Drug delivery systems based on poly(lactide-co-glycolide) and its copolymers The book set is an informative resource for scholars who seek updates in nanomedicine with reference to nanomaterials used in drug delivery systems.

Frontiers in Clinical Drug Research - CNS and Neurological Disorders is a book series that brings updated reviews to readers interested in advances in the development of pharmaceutical agents for the treatment of central nervous system (CNS) and other nerve disorders. The scope of the book series covers a range of topics including the medicinal chemistry, pharmacology, molecular biology and biochemistry of contemporary molecular targets involved in neurological and CNS disorders. Reviews presented in the series are mainly focused on clinical and therapeutic aspects of novel drugs intended for these targets. Frontiers in Clinical Drug Research - CNS and Neurological Disorders is a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critical information for developing clinical trials and devising research plans in the field of neurology. The ninth volume of this series features reviews that cover the following topics related to the treatment of a different CNS disorders, related diseases and basic neuropharmacology research: - Integrating imaging and microdialysis into systems neuropharmacology - Depression heterogeneity and the potential of a transdiagnostic and dimensional approach to identify biologically relevant phenotypes - CAR-T cells in brain tumors and autoimmune diseases from basics to the clinic - Revaluation of thyrotropin-releasing hormone and its mimetics as candidates for treating a wide range of neurological and psychiatric disorders - Natural BACE1 inhibitors: promising drugs for the management of Alzheimers disease - The possibilities of safe lithium therapy in the treatment of neurological and psychoemotional disorders - Pharmacotherapy of multiple sclerosis and treatment strategies

The development of a vector for the delivery of therapeutic drugs in a controlled and targeted fashion is still a major challenge in the treatment of many diseases. The conventional application of drugs may lead to many limitations including poor distribution, limited effectiveness, lack of selectivity and dose dependent toxicity. An efficient drug delivery system can address these problems. Recent nanotechnology advancements in the biomedical field have the potential to meet these challenges in developing drug delivery systems. Nanomaterials are changing the biomedical platform in terms of disease diagnosis, treatment and prevention. Nanomaterials aided drug delivery provides an advantage by enhancing aqueous solubility that leads to improved bioavailability, increased resistance time in the body, decreased side effects by targeting drugs to the specific location, reduced dose dependent toxicity and protection of drugs from early release. In this two-part book, the contributors have compiled reports of recent studies illustrating the promising nanomaterials that can work as drug carriers which can navigate conventional physiological barriers. A detailed account of several types of nanomaterials including polymeric nanoparticles, liposomes, dendrimers, micelles, carbon nanomaterials, magnetic nanoparticles, solid lipid-based nanoparticles, silica nanomaterials and hydrogels for drug delivery is provided in separate chapters. The contributors also present a discussion on clinical aspects of ongoing research with insights towards future prospects of specific nanotechnologies. Part I covers the following topics: · Polymeric nanoparticles · Characterization of nanostructured systems for bioactive compound delivery · Liposomes · Dendrimers · Nanomicelles · Carbon nanotubes · magnetic nanoparticles The book set is an informative resource for scholars who seek updates in nanomedicine with reference to nanomaterials used in drug delivery systems.

Frontiers in Clinical Drug Research Anti infectives is a book series that brings updated reviews to readers interested in learning about advances in the development of pharmaceutical agents for the treatment of infectious diseases. The scope of the book series covers a range of topics including the chemistry, pharmacology, molecular biology and biochemistry of natural and synthetic drugs employed in the treatment of infectious diseases. Reviews in this series also include research on multi drug resistance and pre-clinical / clinical findings on novel antibiotics, vaccines, antifungal agents and antitubercular agents. Frontiers in Clinical Drug Research Anti infectives is a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critically important information for developing clinical trials and devising research plans in the field of anti infective drug discovery and epidemiology. The eighth volume of this series presents comprehensive reviews of interest to readers interested in the treatment of inflammatory diseases, new antiviral agents and strategies, specific antiprotozoal drugs that work against leishmania and helminths, and a study on potential agents against American foulbrood in honey bees. The 7 reviews included in this volume are: - Monoclonal antibodies as therapeutic agents for inflammatory diseases - Pharmacotherapy of emerging antiviral agents - Antiviral activity of vitamin D and COVID-19: current understanding - Anti-infectives to combat leishmaniasis - Anthelmintic drug discovery: current situation and future perspectives - Therapeutic targets for emerging Zika virus infection and vaccines in clinical trials - Agro-industrial waste: new source of raw material for the control of American foulbrood in honey bees

Frontiers in Clinical Drug Research - Anti-Cancer Agents is a book series intended for pharmaceutical scientists, postgraduate students and researchers seeking updated and critical information for developing clinical trials and devising research plans in anti-cancer research. Reviews in each volume are written by experts in medical oncology and clinical trials research and compile the latest information available on special topics of interest to oncology and pharmaceutical chemistry researchers. The seventh volume of the book features reviews on these topics: · Essential oils and monoterpenes as potential anti-cancer agents · Drug delivery systems and emerging immunotherapeutic strategies for the treatment of glioblastoma · CTDNA in solid tumors · Cholesterol treatments (including Pitavastatin) and their potential in cancer treatment

Recent Advances in Analytical Techniques is a series of updates in techniques used in chemical analysis. Each volume presents a selection of chapters that explain different analytical techniques and their use in applied research. Readers will find updated information about developments in analytical methods such as chromatography, electrochemistry, optical sensor arrays for pharmaceutical and biomedical analysis. The fifth volume of the series features five reviews which demonstrate chemical analysis techniques applied in different disciplines. - Superior Aspects of Liquid Chromatography-Based Mass Spectrometers in Chiral Analysis - New Trends in Sample Preparation for Pharmaceutical and Biological Analysis by Chromatographic Methods - Qualitative and Quantitative Investigation of Bio Tissues using Microscopy and Data Mining - Analytical Techniques For Analysis of Metals and Minerals in The Soil Samples - Monitoring Therapeutic Response in Cancers: A Raman Spectroscopy Approach

Advanced Catalysts Based on Metal-organic Frameworks is a comprehensive introduction to advanced catalysts based on MOFs. It covers basic information about MOF catalysts with industrial and environmental applications. The detailed chapters update readers on current applications and strategies to apply MOF-based catalysts in industrial processes geared for sustainability initiatives such as renewable energy, pollution control and combating carbon emissions. Key Features of Part 2 - 7 structured, easy to read chapters that comprehensively cover specific applications of MOF catalysts- In-depth explanation of photocatalytic reactions for multifunctional electrocatalysis, water splitting and CO2 Capture- Notes on MOF materials used in modern processes- Explanation of MOFs in advanced oxidation reactions- Introduction to Electrochemical biosensors- Updated references for advanced readers The is an essential reference for chemical engineers, scientists in the manufacturing and sustainability industry and post-graduate scholars working on MOFs and chemical catalysis.

Fungal Lipid Biochemistry explores the intricate biochemistry of fungal and microbial lipids. The book focuses on recent advances in our knowledge about the distribution, classification, and biochemistry of fungal lipids.The book is divided into four sections, starting with an introduction to fungal lipids which includes definition, classification, nomenclature, and some historical aspects of fungal lipid research. This is followed by an overview of fungal lipids, and environmental and nutritional cultural conditions affecting lipid production. The second section contains four chapters that explain the metabolism of fatty acids, their biosynthetic pathways together with their storage mainly in the form of triacylglycerols. The latter includes a key description of the recently discovered lipid droplet acting as a highly specific cellular compartment for the storage of neutral lipids. The third section contains five chapters concerned with the relatively recent interpretation of other major lipid classes which include glycerophospholipids, sphingolipids, aliphatic hydrocarbons, sterols, carotenoids, and polyprenols and their occurrence and biosynthesis. The final section covers lipid metabolism during fungal development and sporulation. Key features- Extensive coverage of fungal lipid biochemistry, with a focus on recent knowledge- Includes chapters for specific lipid classes with notes on their metabolism- Gives knowledge about the role of lipids in fungal growth and development- Provides references for further reading This book is a comprehensive reference for academics, scientific researchers, and industrial scientists (in biotechnology, food science and nutritional health) who require information about fungal lipid composition and biochemistry.

Fundamentals of Nuclear Physics gives elementary understanding of nuclear and particle physics. The textbook offers an overview of the subject, providing students with a basic understanding about 1) the atomic structure and the nucleus, 2) equipment such as particle detectors, particle accelerators, and nuclear reactors, 3) radioactivity, and 4) elementary particles. Each chapter provides fundamental theoretical and experimental knowledge required for students to strengthen their concepts. Other key features of the book include: - Structured chapters designed for easy reading and stimulating interest for learners - Sophisticated figures - Thoroughly solved equations - Bibliographic references for further reading - Updated information about different types of nuclear reactors - Information about nuclear astrophysics Fundamentals of Nuclear Physics is suitable for introductory undergraduate courses in nuclear physics as well as more innovative courses geared towards nuclear engineering.

The queen honey bee is known to mate with multiple drones, and can produce over a million offspring in its lifetime. Its presence is vital to the growth and survival of a beehive. This reference book is a detailed guide to queen honey bees. The book starts by providing deep insights into the fascinating biologyof the queen honey bees, their morphometric features, developmental synchronicity, genetics, hormones, pheromones, colonial organization and swarming. Further, the book describes artificial queen rearing techniques that facilitate healthy bee colony growth and increase apiculture productivity. The book equips readers with all the knowledge they need to know about queen bee development, their role in the colony and improving the health of their colony. Key Features- 14 reader-friendly chapters that comprehensively present information about queen honey bees- Comprehensive coverage about queen bee biology, including their physical morphology, genetics, proteomics, development and behavior (including worker and drone interactions)- Information about the role of queen bees in colonial organization and life-cycle events- Practical information that helps to improve bee colony health for research and apiculture (disease mechanisms and control, artificial breeding) The book is an essential primary reference on queen honey bees for biology and entomology students, academicians and researchers at all educational levels. Apiculturists, bee keeping enthusiasts, and general readers interested in honey bees can also benefit from the breadth of information presented.

This reference is a timely compilation of studies of genome size and genetic stability of regenerated plants. It presents 13 book chapters that cover recent advancements in CRISPR/Cas-based genome editing, the use of molecular markers to analyze somaclonal variation in tissue culture, and genetic stability assessment in various plant species, including medicinally valuable plants like Valeriana and Coffea. The book also highlights the role of flow cytometry in investigating polyploidy and provides valuable insights into genetic fidelity assessment of micropropagated woody plants and orchids.The contributors have shed light on the intra-specific and inter-specific genome and chromosome number variation with reference to gene duplication and DNA sequence loss. Molecular techniques for detecting ploidy levels and genetic homogeneity in regenerated plantlets are also discussed. Additional highlights of the book include brief guidelines for experimental protocols for flow cytometry and molecular markers, coverage of a wide range of plants, and supporting references. This is an excellent reference for biologists, geneticists, and plant scientists exploring genetic homogeneity and genome size variation in diverse plant groups.

Recent Advances in Analytical Techniques is a series of updates in techniques used in chemical analysis. Each volume presents a selection of chapters that explain different analytical techniques and their use in applied research. Readers will find updated information about developments in analytical methods such as chromatography, electrochemistry, optical sensor arrays for pharmaceutical and biomedical analysis. The sixth volume of the series features five reviews which demonstrate chemical analysis techniques of different materials. - Analytical Techniques for Analysis of Metals and Minerals in Water - Lipidomics Techniques and their Application for Food Nutrition and Health - Recent Advances in the Analysis of Herbicides and their Transformation Products in Environmental Samples - Nanoporous Anodic Aluminum Oxide: An Overview on its Fabrication and Potential Applications - PIXE/PIGE Measurements of Archaeological Glass, its Conceptualization and Interpretation: A Case Study