Recent Advances in Medicinal Chemistry is a book series focused on leading-edge research on developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies. The series presents highly cited contributions first published in the impact factor journal Mini-Reviews in Medicinal Chemistry. Contributors to this volume have updated their work with new experimental data and references following their initial research. Each volume highlights a number of important topics in current research in medicinal chemistry.Selected chapters in this volume include:- Characterization of Inorganic Nanomaterials as Therapeutic Vehicles- HPLC and its Essential Role in the Analysis of Tricyclic Antidepressants in Biological Samples- Tannins and Their Influence on Health And much more.

Frontiers in Computational Chemistry presents contemporary research on molecular modeling techniques used in drug discovery and the drug development process: computer aided molecular design, drug discovery and development, lead generation, lead optimization, database management, computer and molecular graphics, and the development of new computational methods or efficient algorithms for the simulation of chemical phenomena including analyses of biological activity. The third volume of this series features four chapters covering in silico approaches to computer aided drug design, modeling of platinum and adjuvant anti-cancer drugs, allostery in proteins and studies on the theory of chemical space in electron systems.

Pharmaceutical biochemistry is a much-awaited book in the field of Pharmacy. Targeted mainly to B. Pharmacy & Pharm-D students, this book will also be useful for medical, dental, nursing, and other paramedical students. The main objective of this book is to attract undergraduate pharmacy students and make them understand the basic biochemical process which can be applied in Medicinal Chemistry and Pharmacology. Thus, the book is aimed to eliminate the inadequacy in teaching and learning Pharmaceutical Biochemistry by providing detailed information about the biomolecules and their metabolic process.Salient Features: · As per the PCI revised syllabus the coverage is complete with the basics as well as 2nd semester B. Pharm and 1st-year Pharm-D portion. · The content of this book is innovative and presented in 12 chapters with a simple and uniform pattern of explanation along with all biochemical reactions. · To make the learning comfortable and magnetize attention we have used well-labeled diagrams, illustrations, flow charts, simplified and schematic represented biomolecule classification. We have also provided metabolic pathways in an easy-to-understand manner highlighted with chemical structure, type of reaction, energy, and inhibitors, and a detailed and simplified explanation of all biochemical reactions. · Highlighted structural changes in each and every step of biochemical reaction and Metabolic pathway illustration without structure also included for easy revision. · Easy remembrance of enzyme name from the reason behind the naming. · Student-friendly schematic representation of principles for biochemical tests and flow chart representation of a procedure for biochemical tests.Contents:Part I: Basic Biochemistry1. Introduction to Biochemistry2. EnzymesPart II: Biomolecules & its metabolism3. Carbohydrates & Its Metabolism4. Lipids & Its Metabolism5. Protein and Amino Acid Metabolism6. Nucleic Acid & Its MetabolismPart III: Clinical Biochemistry7. Introduction to Clinical Chemistry8. Kidney Function Tests or Renal Function Tests9. Liver Function Test10. Lipid Profile Tests11. Immunochemical Techniques12. Water, Electrolytes and Acid-base Balance

Stem cell and regenerative medicine research is a hot area of research which promises to change the face of medicine as it will be practiced in the years to come. Challenges in the 21st century to combat diseases such as cancer, Alzheimer and related diseases may well be addressed employing stem cell therapies and tissue regeneration. Frontiers in Stem Cell and Regenerative Medicine Research is essential reading for researchers seeking updates in stem cell therapeutics and regenerative medicine. The sixth volume of this series features reviews on roles of mesenchymal stem cells in cartilage regeneration and bone regeneration, liver regeneration, cardiogenesis, cardiomyocyte differentiation, and regenerative therapy for neurodegenerative disorders.

Extremophiles: Diversity, Adaptation and Applications brings up-to-date knowledge about different types of extremophiles, the fascinating group of microorganisms that love to live in extreme environmental conditions. The book consists of fourteen chapters, of which, the first provides an overview of all the major types of extremophiles and the relationship with their respective extreme environments. The chapters following this introduction explain the diversity of prokaryotes based on environmental conditions, adaptation mechanisms, and industrial applications. The book concludes with a summary of the diverse biotechnological and industrial applications of extremophiles, emphasizing the importance of these microorganisms for human welfare. The book is intended as a primary textbook reference that enriches the knowledge base of scholars in the field of microbiology and biotechnology. It can also serve as a secondary reference for anyone who is interested in research on extremophiles. Key Features - Covers all the major types of extremophiles, including hyperthermophiles, psychrophiles, halophiles, acidophiles, alkaliphiles, xerophiles, oligotrophs, chemolithotrophs, anaerobes and others - Provides a fundamental overview of the microbiology of extreme environments - Supplements fundamentals with information about industrial and scientific applications - Presents information in a simple structured format suitable for learners - Includes references for further reading

Increasing public health concern about healthy lifestyles has sparked a greater demand among consumers for healthy foods. Natural ingredients and environmental friendly food production and processing chains are more aligned to meeting the demand for healthy food. There is a wide array of food additives and chemicals that have nutritional value. The biotechnological food production processes, therefore, vary for different types of food chemicals and ingredients accordingly.Biotechnological Production of Natural Ingredients for Food Industry explains the main aspects of the production of food ingredients from biotechnological sources. The book features 12 chapters which cover the processes for producing and adding a broad variety of food additives and natural products, such as sweeteners, amino acids, nucleotides, organic acids, vitamins, nutraceuticals, aromatic (pleasant smelling) compounds, colorants, edible oils, hydrocolloids, antimicrobial compounds, biosurfactants and food enzymes. Biotechnological Production of Natural Ingredients for Food Industry is a definitive reference for students, scientists, researchers and professionals seeking to understand the biotechnology of food additives and functional food products, particularly those involved in courses or activities in the fields of food science and technology, food chemistry, food biotechnology, food engineering, bioprocess engineering, biotechnology, applied microbiology and nutrition.

Fluorescence Microscopy is a precise and widely employed technique in many research and clinical areas nowadays. Fluorescence Microscopy In Life Sciences introduces readers to both the fundamentals and the applications of fluorescence microscopy in the biomedical field as well as biological research. Readers will learn about physical and chemical mechanisms giving rise to the phenomenon of luminescence and fluorescence in a comprehensive way. Also, the different processes that modulate fluorescence efficiency and fluorescence features are explored and explained. Key learning points covered in the book include: Operation of fluorescence microscopy instruments as well as the different options available today for the scientist, from the classical to the most recent approaches The wide range of biological detection possibilities that fluorescence microscopy offers in molecular biology, cell biology, histology and histopathology Fluorescent chemical compounds Breakthroughs in this field, such as non-linear microscopies and super-resolution techniques Fluorescence Microscopy In Life Sciences is intended as a detailed guide for professionals, researchers and students (including graduates Ph.D. candidates) in life sciences, with special emphasis in the biomedical field. Researchers working in allied disciplines such as pharmacology, veterinary sciences and microbiology will also benefit from the information presented in this handbook.

Stem cell and regenerative medicine research is a hot area of research which promises to change the face of medicine as it will be practiced in the years to come. Challenges in the 21st century to combat diseases such as cancer, Alzheimer and related diseases may well be addressed employing stem cell therapies and tissue regeneration. Frontiers in Stem Cell and Regenerative Medicine Research is essential reading for researchers seeking updates in stem cell therapeutics and regenerative medicine. This volume includes reviews on the following topics: -the role of microvesicles and exosomes in mesenchymal stem cell (MSCs) in treating diseases while overcoming side effects-alternative models for understanding cancer stem cell biology-stem cells treatments for orthopaedic injury and endocrine disorders-wound healing biomaterials-theoretical models of hematopoietic cell dynamics (with implications for bone marrow transplants)

Frontiers in Clinical Drug Research - Alzheimer Disorders is a book series concerned with Alzheimer;s disease (AD), a disease that causes dementia, or loss of brain function. This disease affects parts of the brain that affect memory, thought, and language. Chapters in each volume focus on drug research with special emphasis on clinical trials, research on drugs in advanced stages of development and cure for Alzheimers disease and related disorders. Frontiers in Clinical Drug Research - Alzheimer Disorders will be of particular interest to readers interested in drug therapy of this specific neurodegenerative condition and related brain disorders as the series provides relevant reviews written by experts in the field of Alzheimers disease research. The seventh volume of this series features chapters covering critical discussions on AD biochemistry and new therapies. The reviews in this volume include:- Deep Brain Stimulation in the Treatment of Alzheimer;s disease- ASS234: A New and Promising Anti-Alzheimer Agent- Recent Advances in Alzheimer;s Drug Discovery Research- Alzheimers Disease and Proteasome: The Therapeutic Development and Management- Alzheimers Disease: Fundamental Concepts, Novel Findings and Therapeutics Outcomes Coming from the Ca2+/cAMP Signalling Interaction- Alzheimer;s Disease: An Approach for Non-Pharmacological Therapies- Past and Present Drug Development for Alzheimer;s Disease.

Frontiers in Computational Chemistry presents contemporary research on molecular modeling techniques used in drug discovery and the drug development process: computer aided molecular design, drug discovery and development, lead generation, lead optimization, database management, computer and molecular graphics, and the development of new computational methods or efficient algorithms for the simulation of chemical phenomena including analyses of biological activity. The fourth volume of this series features five chapters covering natural lead compounds, computer aided drug discovery methods in Parkinsons Disease therapeutics, studies of aminoacyl tRNA synthetase inhibition in bacteria, computational modeling of halogen bonds in biological systems and molecular classification of caffeine and its metabolites.

Determining the presence of different types of toxic compounds (or xenobiotics) in food requires precise analytical methodologies. Examples of these techniques include separation techniques coupled to mass spectrometry, Variations in methods used depend on the physicochemical properties of each xenobiotic being tested for.Advances in the Determination of Xenobiotics in Foods explains recent developments in the field of xenobiotic determination in food. Readers are introduced to xenobiotic testing techniques through extensive reviews. Chapters also cover details about contaminants coming from food contact materials (such as plasticizers, food additives, polymer monomers/oligomers and non-intentionally added substances), substances used for food processing and sensing (nanoparticles), and residues of pesticides (that can also be present in the final food product). The book also includes information about specific xenobiotics that, due to their global distribution in the environment, are also likely to enter the food chain. Some of them are regulated (persistent organic pollutants and heavy metals) but there are many other types of contaminants (halogenated flame-retardants, perfluorinated compounds and micro- and nanoplastics) that must also be controlled. In addition, some xenobiotics could be present in the final food consumed because of food treatments (acrylamide, furan, heterocyclic aromatic amines, and glycidol esters). Finally, the concluding chapters of the book are devoted to the presence of natural contaminants such as mycotoxins and biogenic amines.The combination of extensive information of analytical techniques for xenobiotics along with a categorical treatment of food contaminants makes this volume a handy reference for food science and technology students and technicians involved in food safety and processing management roles.

When environmental conditions deviate from the optimal range, stress ensues. Stress response is a set of reactions that allow the organism to adjust and survive adverse conditions. Stress can be physical, such as extreme temperature, radiation, injury, or psychological, caused by perceived danger or deprivation. Every living cell has biochemical mechanisms to cope with physical stress. These mechanisms show a degree of similarity among several types of living organisms. Stress Response and Immunity: Links and Trade Offs explores the functional and evolutionary connections between stress response and immunity. The book introduces the reader to the concept of stress and subsequently examines the connection between stress response and immunity at various evolutionary stages of living organisms - from bacteria to humans. The book also features chapters dedicated to the role of tumor suppressor genes and the immune system of the brain. The information presented in this reference demonstrates the profound effects of physical and psychological stress on human health. Readers with basic knowledge of molecular biology will learn about the interesting facets of stress responses and the evolutionary trade offs observed in different life forms.

Stem cell and regenerative medicine research is an important area of clinical research which promises to change the face of medicine as it will be practiced in the years to come. Challenges in the 21st century to combat diseases such as cancer, Alzheimers disease and retinal disorders, among others, may well be addressed employing stem cell therapies and tissue regeneration techniques. Frontiers in Stem Cell and Regenerative Medicine Research is essential reading for researchers seeking updates in stem cell therapeutics and regenerative medicine. This volume includes current literature on a variety of topics: -the utility of exogenous and endogenous neural stem cells in spinal cord injury -somatic cells for human induced pluripotent stem cells (iPSCs) -reactive oxygen species (ROS) mediated cellular signaling for stem cell differentiation -the therapeutic potential of microRNAs in cardiac diseases -stem cell therapy for the treatment of malaria

Since ancient times, yeasts have been used for brewing and breadmaking processes. They now represent a flagship organism for alcoholic fermentation processes. The ubiquity of some yeast species also offers microbiologists a heterologous gene-expression platform, making them a model organism for studying eukaryotes. Yeasts: from Nature to Bioprocesses brings together information about the origin and evolution of yeasts, their ecological relationships, and the main taxonomic groups into a single volume. The book initially explores six significant yeast genera in detailed chapters. The book then delves into the main biotechnological processes in which both prospected and engineered yeasts are successfully employed. Yeasts: from Nature to Bioprocesses, therefore, elucidates the leading role of these single-cell organisms for industrial microbiology in environmental, health, social, and economic terms. This book is a comprehensive, multidisciplinary resource for general readers as well as scholars of all levels who want to know all about yeast microbiology and their industrial applications.

This book describes nuclear magnetic resonance (NMR) methods which are used to study translational dynamics of molecules in different complex systems including systems made of synthetic and natural polymers, tissues and the porous heterogeneous systems of different types, such as cement and wood. The results of proton spin-lattice and spin-spin relaxation, cross-relaxation, pulse field gradient (PFG) NMR in studying diffusion properties and dynamics of molecules in polymer systems of different complexity are reported. In addition to these methods, reports on the use of the double-quantum-filtered (DQF) NMR technique in a study of slow molecular dynamics and properties of systems with anisotropic properties, such as water in hardening cement pastes, are presented. The book also covers applications of one and two dimensional NMR techniques.This book is a useful reference for readers learning different NMR techniques and their applications in civil engineering and biochemistry.

In this book, all the chapters adequately cover the basic concepts of Engineering Mechanics with maximum emphasis on solving the problems in a lucid manner so that average student can understand easily. Although the author does not claim complete originality, an attempt is made that the book is self sufficient eliminating the need for reference to other books. S.I. units have been used for numerical problems however in chapters dealing with Centroids and Moment of Inertia some dimensions are in milli meters.Syllabus covered in this book caters not only to the needs of Mechanical, Civil, Production, Automobile, Mechatronics and Aeronautical Engineering students of JNTUH but students of all Universities. The problems solved are useful for students preparing for IES, GATE and all other competitive examinations.Contents:1. Introductory Concepts2. System of Force3. Equilibrium of Force System4. Analysis of Structures5. Friction6. Centroids7. Moment of Inertia8. Virtual Work9. Kinematics of Particle10. General Principles of Dynamics11. Kinetics of Particles12. Kinematics of Rigid Bodies13. Mechanical Vibration14. Work Energy Method15. Impulse and Momentum

This volume is addressed to historians of science, Egyptologists and Assyriologists dealing with the history of early science. It presents the proceedings of two workshops held at the Goethe-University Frankfurt/Main, focusing on traditions of systematic knowledge in Ancient Egypt and Mesopotamia. Assuming that written knowledge was preserved and transmitted intentionally in both cultures, paradigms of knowledge can be reflected by the texts. Although the available source material is subject to their find spots and the vagaries of preservation, by asking specific questions the sources can provide insights into the work of the ancient scholars. The text corpora presented in this volume come from the fields of medicine, magic and ritual, astronomy, mathematics and law. The authors use the sources to provide overviews of the discussed knowledge areas and to discuss certain aspects of the traditions in more detail.

Applications of NMR Spectroscopy is a book series devoted to publishing the latest advances in the applications of nuclear magnetic resonance (NMR) spectroscopy in various fields of organic chemistry, biochemistry, health and agriculture.The third volume of this book series features six reviews covering structure-property relationship of polyphenols, NMR spectroscopy in breast cancer diagnosis, NMR methods in drug discovery and formulation, protein confirmation analysis using Fluorine NMR and NMR studies enaminones.

Increased industrial and agricultural activity has led to the contamination of the earths soil and groundwater resources with hazardous chemicals. The presence of heavy metals, dyes, fluorides, dissolved solids, and many other pollutants used in industry and agriculture are responsible for hazardous levels of water pollution. The removal of these pollutants in water resources is challenging. Bioremediation is a new technique that employs living organisms, usually bacteria and fungi, to remove pollutants from soil and water, preferably in situ. This approach is more cost-effective than traditional techniques, such as incineration of soils and carbon filtration of water. It requires understanding how organisms consume and transform polluting chemicals, survive in polluted environments, and how they should be employed in the field. Bioremediation for Environmental Pollutants discusses the latest research in green chemistry and practices and principles involved in quality improvement of water by remediation. It covers different aspects of environmental problems and their remedies with up-to-date developments in the field of bioremediation of industrial/environmental pollutants. Volume 2 explains the methods used to control the remediation processes making it cost-effectively and feasible. It elaborates on the application of microbial enzymes, microalgae, and genetically engineered microorganisms in the bioremediation of significant pollutants, food wastes, distillery wastewater, and pharmaceutical wastes. This book is invaluable for researchers and scientists in environmental science, environmental microbiology, and waste management. It also serves as a learning resource for graduate and undergraduate students in environmental science, microbiology, limnology, freshwater ecology, and microbial biotechnology.

Increased industrial and agricultural activity has led to the contamination of the earths soil and groundwater resources with hazardous chemicals. The presence of heavy metals, dyes, fluorides, dissolved solids, and many other pollutants used in industry and agriculture are responsible for hazardous levels of water pollution. The removal of these pollutants in water resources is challenging. Bioremediation is a new technique that employs living organisms, usually bacteria and fungi, to remove pollutants from soil and water, preferably in situ. This approach is more cost-effective than traditional techniques, such as incineration of soils and carbon filtration of water. It requires understanding how organisms consume and transform polluting chemicals, survive in polluted environments, and how they should be employed in the field. Bioremediation for Environmental Pollutants discusses the latest research in green chemistry and practices and principles involved in quality improvement of water by remediation. It covers different aspects of environmental problems and their remedies with up-to-date developments in the field of bioremediation of industrial/environmental pollutants. Volume 1 focuses on the bioremediation of heavy metals, pesticides, textile dyes removal, petroleum hydrocarbon, microplastics and plastics. This book is invaluable for researchers and scientists in environmental science, environmental microbiology, and waste management. It also serves as a learning resource for graduate and undergraduate students in environmental science, microbiology, limnology, freshwater ecology, and microbial biotechnology.