Ebooks de ciencias, página 14 de 708

This volume presents information about protocols for micropropagation of more than 40 species of medicinal plants. The contents combine knowledge about the scientific principles of micropropagation with state of the art updates in tissue culture techniques presented by plant scientists. The readers will learn about techniques required to grow plants in challenging conditions that aim to reduce the impacts of injudicious harvesting, deforestation, climate change, pollution, urbanization and other factors that limit the ability to meet current demand. General topics such as biotization and pharmaceutical investigation are also included to guide readers about the significance of these plants in research and development for new medicines. The book provides protocols for micropropagation of important medicinal plants like Rauvolfia serpentina, Catharanthus roseus, Withania somnifera, Tylophora indica, Bacopa monnieri, Aloe vera, Phyllanthus amarus, Allium sativum, Moringa oleifera, Operculina turpethum, Glycyrrhiza glabra, Pterocarpus marsupium, Vetiver grass, Ruta graveolens, Tinospora cordifolia, Kaempferia, Hedychium, Decalepis hamiltonii, Saraca asoca, Wrightia tinctoria, Wrightia arborea, Artemisia absinthium, Aegle marmelos, Atropa acuminata, Atropa belladonna, Alpinia species, Hedychium species, and Cissus species. This book is a handy reference for medicinal chemists, horticulturists and pharmacists who want to learn about the growth and conservation of important medicinal herbs and plants. Readership Medicinal chemists, horticulturists and pharmacists.

This reference is a comprehensive review of genome editing in bacteria. The multi-part book meticulously consolidates research findings and insights on the applications of bacteria across several industries, including food processing and pharmaceutical development. The book covers four overarching themes for readers: a historical perspective of genome editing, genome editing in probiotics, applications of genome editing in agricultural microbiology and genetic engineering in environmental microbiology. The editors have also compiled chapters that provide an in-depth analysis of gene regulation and metabolic engineering through genome editing tools for specific bacteria. Key topics in part 2: - Targeting pathogenic microbes for plants and animals using CRISPR-CAS - Genome editing microbes to improve crop yield plant growth for sustainable agriculture - Applications of genome editing for bioremediation - Microbial genome editing for environmental bioprocessing - Genetic engineering for methanotrophs - Genome engineering in Cyanobacteria - Genome editing in Streptomyces Genome Editing in Bacteria is a definitive reference for scholars, researchers and industry professionals navigating the forefront of bacterial genomics. Readership Scholars and professionals interested in bacterial genomics.

Software and Programming Tools in Pharmaceutical Research is a detailed primer on the use for computer programs in the design and development of new drugs. Chapters offer information about different programs and computational techniques in pharmacology. The book will help readers to harness computer technologies in pharmaceutical investigations. Readers will also appreciate the pivotal role that software applications and programming tools play in revolutionizing the pharmaceutical industry. The book includes nine structured chapters, each addressing a critical aspect of pharmaceutical research and software utilization. From an introduction to pharmaceutical informatics and computational chemistry to advanced topics like molecular modeling, data mining, and high-throughput screening, this book covers a wide range of topics. Key Features: · Practical Insights: Presents practical knowledge on how to effectively utilize software tools in pharmaceutical research. · Interdisciplinary Approach: Bridges the gap between pharmaceutical science and computer science · Cutting-Edge Topics: Covers the latest advancements in computational drug development, including data analysis and visualization techniques, drug repurposing, pharmacokinetic modelling and screening. · Recommendations for Tools: Includes informative tables for software tools · Referenced content: Includes scientific references for advanced readers The book is an ideal primer for students and educators in pharmaceutical science and computational biology, providing a comprehensive foundation for this rapidly evolving field. It is also an essential resource for pharmaceutical researchers, scientists, and professionals looking to enhance their understanding of software tools and programming in drug development. ReadershipPharmaceutical researchers, scientists, and professionals; students and educators in pharmacology and computational biology.

Biotechnology and Drug Development for Targeting Human Diseases is an insightful compendium on drug development technologies for professionals and students in biotechnology and pharmacology. This book meticulously explores the intersection of biotechnology with drug development, emphasizing its crucial role in creating new therapies for human disease. Central to the book is the innovative use of biotechnology in understanding and treating diseases. It begins with an exploration of multi-omics profiles, shedding light on disease mechanisms and drug development. Subsequent chapters explain in silico methods for drug design, the role of natural products in antimicrobial applications and wound healing, and the use of viruses as carriers in biotechnology. Key features of this reference include a blend of theoretical knowledge and practical insights, detailed analyses of molecular docking in drug discovery, the repurposing of drugs for various diseases, and the emerging field of omics technologies in drug interaction studies. Each chapter is comprehensive, offering current information backed by extensive references, making the book both a foundational and advanced resource. Readership Students and professionals in the fields of biotechnology and pharmacology.

This book summarizes the cutting-edge experimental research on heterocyclic compounds used as anti-inflammatory agents in ten chapters. Each chapter is authored by experts in medicinal chemistry and is supplemented with scientific references for advanced reading. The book covers several types of heterocyclic compounds and their derivatives including · pyrimidine and pyrimidinone derivatives · 1,2,3, and 1,2,4 triazoles · imidazole and benzimidazole derivatives · oxazole, oxadiazole, isoxazoline, and oxazoline derivatives · thiazole and thiazolidinone derivatives · pyrazole and pyrazoline · carbazoles and their derivatives · azipines, quinolines, and coumarins This is a timely reference for medicinal chemists interested in developing new heterocycles for anti-inflammatory drugs. Contributors have discussed the effects of these compounds on different types of inflammation and their evolution in drug development as a therapeutic agent to give a wider perspective to readers.

This comprehensive volume is a review on the pivotal role of seaweeds in the blue bioeconomy. It begins by introducing the blue bioeconomy concept which encompasses the use of renewable biological marine resources to produce food, materials and energy. The book then continues to explore the applications of seaweeds. Chapters cover the biomedical applications (nutraceuticals), functional applications (functional ingredients, biofertilizers), and commercial applications (cosmeceuticals, animal feeds) of seaweeds. Each chapter is structured into sections to provide an easy to understand summary of respective topics, with detailed discussions that reveal the intricate nature of seaweeds. The book shares perspectives from experts in environmental science and biology, with references for advanced readers. The book is for anyone who wants to understand the role of seaweeds in the bioeconomy and for sustainable development. Readership Industrialists, policymakers, scientists, students and science readers.

This reference presents information about models utilized in experimental medicine and pharmaceutical research and development for several human diseases. Written by experts in immunology, cancer biology and pharmacology, the book provides readers with handy notes and updated data on animal models that are critical to research planning and lab execution. The main feature of the book is a set of 12 structured chapters that focus on a specific disease such as cancer, infectious diseases, autism, autoimmune diseases, Alzheimers disease and anemia. The contributors have gathered information on a wide range of genetic and physiological animal models that are employed in research with comparative charts that highlight their main differences. The book also includes chapters for special topics like food allergies and dentistry. Additional features of the book are an explanation of disease mechanisms that give an easy understanding, notes for idiopathic models and specific clinical conditions, and a list of references for advanced readers. Animal Models In Experimental Medicine is essential reading for scholars, graduate students and senior researchers in life sciences and clinical medicine. It also serves as a resource for professionals involved in bench-to-bedside pharmaceutical projects. Readership Scholars, graduate students and senior researchers in life sciences and clinical medicine; professionals involved in bench-to-bedside pharmaceutical projects.

This book focuses on cases and studies of interest to mechanical engineers and industrial technicians. The considered applications in this volume are widely used in several industrial fields particularly in the automotive and aviation industries. Readers will understand the theory and techniques which are used in each application covered in each chapter. Volume 2 includes the following topics: Numerical investigation of turbulent slot jets with various nanoparticle shapes Experimental study on a sweeping gas membrane distillation unit Development of design processes for multi-spindle drilling using a neural network and expert systems Experimental investigation of a new hybrid solar collector (PV/t) system Theoretical study of the effects of combustion duration on engine performance Effects of preheating temperature and fuel-air equivalence ratio on pollution control in hydrocarbon combustion Numerical study of natural convection between two concentric ellipses with different shapes and imposed temperatures Theoretical study of the geometrical parameters effect on the behavior of a solar chimney power plant Numerical investigations of the effect of packed bed porosity on the flow behavior Comparison between a conventional and a four-stage Savonius wind rotor The presented case studies and development approaches aim to provide readers with basic and applied information broadly related to mechanical engineering and technology.

Advances in biomedical research have had a profound effect on human health outcomes over the last century. Biophysical, biochemical and cellular techniques are now the backbone of modern biomedical research. Understanding these laboratory techniques is a prerequisite for investigating the processes responsible for human diseases and discovering new treatment methods. Cutting Edge Techniques in Biophysics, Biochemistry and Cell Biology: From Principle to Applications Provides information about basic and advanced analytical techniques applied in specific areas of life science and biomedical research. Key Features: - Book chapters present a broad overview of sophisticated analytical techniques used in biophysics, biochemistry and cell biology. - Techniques covered include in vitro cell culture techniques, flow cytometry, real time PCR, X-ray crystallography, RNA sequencing - Information about industrial and biomedical applications of techniques, (drug screening, disease models, functional assays, disease diagnosis, gene expression analysis and protein structure determination) is included. The book is an excellent introduction for students (as a textbook) and researchers (as a reference work). The information it presents will prepare readers to understand and develop research methods in life science laboratories for different projects and activities.

Protocols used in Molecular Biology is a compilation of several examples of molecular biology protocols. Each example is presented with a concise introduction, materials and chemicals required, a step-by-step procedure and troubleshooting tips. Information about the applications of the protocols is also provided. The techniques included in this book are essential to research in the fields of proteomics, genomics, cell culture, epigenetic modification and structural biology. The protocols can also be used by clinical researchers (neuroscientists and oncologists, for example) for medical applications (diagnostics, therapeutics and multidisciplinary projects). Techniques explained in this reference include: - Nucleic Acid (DNA/RNA) isolation - Next-generation sequencing through real time PCR - Western Blotting - 2-D gel electrophoresis - Immunohistochemistry - Chromatin immunoprecipitation (ChIP) - Live cell-culture techniques - Golgi Staining Key Features: - Recent laboratory protocols - Diverse examples of molecular biology experiments - Simple step-by-step presentation of information - Special focus on scientific and clinical applications Protocols used in Molecular Biology is essential reading for academicians, molecular biologists, as well as graduate and undergraduate students studying basic and applied research. Pharmacologists, and medical researchers can also benefit from the wide array of techniques presented in the book.

A Primer on Earth Pollution: Pollution Types and Disposal, is an encyclopedia of important research articles and short essays on pollution. Chapters in the initial half provide information about a wide variety of pollutants (dyes and microplastics) and contributing factors (thermal pollution and the impact of GM plants, for instance). Each chapter explains the nature of polluting agents and presents notes and references on preventive measures. Notes on the associated clinical complications due to exposure are also proved where applicable, such as the case of MDR bacteria in marine environments. The latter chapters of the book cover the biotechnology of medical waste disposal using microbes as well as nanotechnology used for limiting the spread of COVID-19. The volume is a handy reference for students and trainees in the field of environmental science as it brings a balance of basic and applied information on the subject of pollution.

In this handbook, the authors provide a practical, easily accessible guide of necropsy techniques for examining wildlife. Chapters introduce the reader to the value of necropsy in studying wildlife in general, sample collection methods, cadaveric phenomena and necropsy techniques for a variety of organisms ranging from invertebrates to mammals. The book addresses some of the peculiar characteristics of veterinary autopsy specific to different types of specimens. The goal of this book is to equip the reader with the information necessary to conduct a forensic examination in order to reach a conclusive diagnosis of an animals death, while also understanding it in an ecological context. Necropsy Techniques for Examining Wildlife Samples is intended as an essential handbook for students and professionals of biology, zoology and veterinary medicine as well as professionals, who work in natural parks, wildlife rehabilitation centers and biological or zoological parks as conservationists, researchers or animal handlers.

Exercises in Organic Synthesis Based on Synthetic Drugs presents information on topics about the synthesis of biologically active compounds which are used against a range of diseases in both humans and animals. Topics are supplemented by notes and exercises for students to stimulate inquiry and learning in the academic environment. Readers will be equipped with basic knowledge of synthetic techniques used in organic chemistry and pharmaceutical research and development. Key Features: - Presents information about different techniques and strategies for the synthesis of organic compounds- Covers a broad range of biologically active compounds- Easy to read topical presentation- Exercises, with answers, designed for improving concepts in organic synthesis and medicinal chemistry- Wide range of bibliographic references for further reading and exercises presented, Exercises in Organic Synthesis Based on Synthetic Drugs is an essential textbook for students in beginner level courses in organic chemistry, organic synthesis and medicinal chemistry.

This book focuses on cases and studies of interest to mechanical engineers and industrial technicians. The considered applications in this volume are widely used in several industrial fields particularly in the automotive and aviation industries. Readers will understand the theory and techniques which are used in each application covered in each chapter. Volume 3 includes the following topics: Numerical simulations of three-dimensional laminar mixed convection heat transfer of water-based-Al2O3 nanofluid in an open cubic cavity with a heated block.Nonlinear formulations of Element-Free Galerkin Method (EFGM) for large deformation analysis of Ogdens hyperelastic materials, emphasizing incompressibility and mesh distortion avoidance.Development of a 3D numerical model with LS-DYNA using a coupled SPH-FEM method to simulate hydraulic behavior of a Ski-Jump Spillway with dentates, showcasing precision through validation.Exploration of enhancing the inlet system of an LPG-H2 fueled engine using a static inclined blade turbine, analyzed through Computational Fluid Dynamics (CFD) simulations.Effective utilization of Artificial Neural Networks (ANN) in heat transfer applications, addressing issues like fouling in heat exchangers, showcasing their accuracy compared to experimental data.Investigation of the impact of nitrogen concentration on the structure and properties of ZrN coatings deposited by magnetron sputtering, evaluating variations in structural and mechanical properties.Forced convection in a horizontal cylindrical pipe with pseudoplastic fluid, considering uniform constant heat flux and uniform temperature as boundary conditions.Modeling and experimental study of a water solar collector coupled to an optimized solar still, aiming to enhance freshwater production in a solar distillation system under specific climatic conditions.Exploration of the effect of film thickness on the structure and properties of Ti-N films deposited by magnetron sputtering, utilizing theoretical and experimental analysis to confirm the rock salt TiN structure.The presented case studies and development approaches aim to provide readers with basic and applied information broadly related to mechanical engineering and technology. Readership Graduate students, PhD candidates and professionals seeking basic and applied information related to mechanical engineering and technology.

Recent Progress in Pharmaceutical Nanobiotechnology: A Medical Perspective offers a comprehensive exploration of the dynamic field of pharmaceutical nanobiotechnology, focusing on its medical applications. This edited reference serves as a valuable resource for researchers, students, and professionals in various disciplines (pharmacology, biotechnology, clinical medicine and nanotechnology) , providing insights into the latest advancements and practical implications of nanotechnology in the pharmaceutical sector. The book presents 14 edited and referenced chapters that cover several themes for readers. General Pharmaceutical Nanobiotechnology:Introduction to the interdisciplinary fieldExploration of nanoscale materials for medical purposesNanoparticle Development and Applications:Bioinspired NanomedicinesLipid-Based NanocarriersMetallic Nanoparticles and Their ApplicationsNanoparticle Targeting StrategiesNanomedicine-Based Therapies for Cancer Stem CellsBiotechnological Aspects:Biotechnological Significance of ExosomesGlycoconjugates: Biosynthesis and FunctionsInnovative Nanotherapies:Novel Nanotechnological Approaches for GlioblastomaBiocompatibility of Nanomedicines and Bio CoronaDiagnostic and Sensing Applications:Role of Nanoparticular/Nano Vesicular Systems as BiosensorsIn Vitro Applications of Drug-Carrying Nanoparticles in Cell Culture StudiesIn Vivo Imaging Techniques: Bioluminescence and Fluorescence ImagingPrecision Medicine:The Role of Nano and Biopharmaceutics in Precision Medicine Audience Postgraduate researchers in pharmaceutical biotechnology; pharmacy professionals and academicians

The knowledge of plant responses to various abiotic stresses is crucial to understand their underlying mechanisms as well as the methods to develop new varieties of crops, which are better suited to the environment they are grown in. Environmental Stress Physiology of Plants and Crop Productivity provides readers a timely update on the knowledge about plant responses to a variety of stresses such as salinity, temperature, drought, oxidative stress and mineral deficiencies. Chapters focus on biochemical mechanisms identified in plants crucial to adapting to specific abiotic stressors along with the methods of improving plant tolerance. The book also sheds light on plant secondary metabolites such as phenylpropanoids and plant growth regulators in ameliorating the stressful conditions in plants. Additional chapters present an overview of applications of genomics, proteomics and metabolomics (including CRISPR/CAS techniques) to develop abiotic stress tolerant crops. The editors have also provided detailed references for extended reading to support the information in the book. Environmental Stress Physiology of Plants and Crop Productivity is an informative reference for scholars and researchers working in the field of botany, agriculture, crop science and physiology, soil science, and environmental sciences.

This book presents information about the high enzymatic reactivity of reactive oxygen species. Chapters in the book cover several aspects of the topic such as the sources, formation mechanisms, reaction centers, oxidation-reduction reactions, cellular respiration chemistry, enzymatic kinetics, mitochondrial and plastid electron transport chains, oxidation-reduction potential, reaction constants, reaction velocity and reaction mechanisms involved, cellular cytotoxicity, antioxidant defense mechanisms in plants and animals, response of plants to conditions of environmental stress, xenobiotics, and the thermodynamics inherent to oxygen metabolism. The book also features a chapter on flavonoids which highlights a paradoxical facet of the affinity of reactive oxygen species for enzymes. Flavonoids are mainly antioxidant molecules as they act as trappers of reactive oxygen species. The chapter informs readers about the metabolic pathways mediated by enzymes through wich flavonoids become promoters of these same reactive oxygen species. All chapters present the subject in a simple, analytical format, while highlighting the scientific evidence gathered by researchers so far. The volume is an interesting reference for scholars learning about the biochemistry and enzymology of oxygen and its free radical derivatives.

Aluminium is a chemical element present in earths crust and it is a known environmental toxin which has been found to be associated with various neurological disorders. Aluminium has been found to be a very strong risk factor for the development of Alzheimers disease. Biochemical Mechanisms of Aluminium Induced Neurological Disorders explains the association of aluminium with neurological disorders. The book introduces the reader to sources of aluminium exposure, followed by an explanation of pharmacokinetics of aluminium and the different biochemical pathways that cause neurological effects. Chapters cover the typical mechanisms associated with aluminium neurotoxicity such as synaptic impairment as well as recent topics of interest such as the role of aluminum in impairing blood-brain barrier functions. Separate chapters which cover clinical evidence of aluminium toxicity and its management are also included in the book. Biochemical Mechanisms of Aluminium Induced Neurological Disorders is a concise, yet informative reference on the subject of aluminium neurotoxicity for all readers, whether they are students of biochemistry, pharmacology and toxicology, clinical neurologists, environmentalists interested in metal pollution or general readers who want to learn about the toxic effects of aluminium in humans.

This book focuses on cases and studies of interest to mechanical engineers and industrial technicians. The considered applications in this volume are widely used in several industrial fields particularly in the automotive and aviation industries. Readers will understand the theory and techniques which are used in each application covered in each chapter. The book contents include the following topics: Numerical analysis of hydrokinetic turbines Computational fluid dynamics of a CuO based nanofluid in mini-channel cross-sections Orthodontic biomechanics of a NiTi arch wires Reynolds number effects on fluid flow through Savonius rotors Effect of operating parameters on Zn-Mn alloys deposited from additive-free chloride bath Optical properties and stability of a blue-emitting phosphor (Sr2P2O7:Eu2+) Under UV and VUV excitation Numerical study of the influence of nanofluid type on thermal improvement in a three dimensional mini channel Electrochemical studies and characterization of Zn-Mn coatings deposited in the presence of novel organic additives Prediction of fire and smoke propagation under a range of external conditions Structural design of a 10 kW H-Darrieus wind turbine The presented case studies and development approaches aim to provide the readers, such as graduate students, PhD candidates and professionals with basic and applied information broadly related to mechanical engineering and technology.

Chemistry of Bipyrazoles: Synthesis and Applications covers the synthetic pathways for all types of bipyrazoles. 5 chapters cover bipyrazole systems, N,N- and N,C-bipyrazoles, namely 1,1`-bipyrazole, 1,3`-bipyrazole, 1,4`-bipyrazole, 3,3`-bipyrazoles, 3,4`-bipyrazoles and 4,4`-bipyrazoles The contents explain several types of reactions: 1) condensation reactions of hydrazines with tetracarbonyls, dihydroxydicarbonyl compounds or pyrazole-based difunctional compounds; 2) 1,3-dipolar cycloaddition of pyrazole-based hydrazonoyl halides with activated methylene compounds; 3) metal catalyzed cross-coupling reactions. The book concludes with a chapter that details the applications of bipyrazole derivatives in different industries. Information about advanced concepts used in chemical engineering such as metal-organic frameworks (MOFs) and corrosion inhibition are highlighted. The book contents are presented in an easy-to-understand manner suitable for readers in organic chemistry at senior levels of education and industry expertise. Each chapter is supplemented with detailed references.