Ebooks de ciencias, página 6 de 700

Frontiers in Clinical Drug Research - Anti-Cancer Agents is a book series intended for pharmaceutical scientists, postgraduate students and researchers seeking updated and critical information for developing clinical trials and devising research plans in anti-cancer research. Reviews in each volume are written by experts in medical oncology and clinical trials research and compile the latest information available on special topics of interest to oncology researchers. The fifth volume of the book features reviews on biochemical inhibitors (second-generation protein kinase Inhibitors, histone deacetylase inhibitors, immune checkpoint inhibitors, EGFR Tyrosine Kinase inhibitors, non-coding RNAs), apoptosis, and physical exercise therapy for cancer patients undergoing chemotherapy. The treatment strategies in this volume cover cancers such as acute myeloid leukemia, gastrointestinal cancer, breast cancer and lung cancer.

Frontiers in Clinical Drug Research - Alzheimer Disorders is a book series concerned with Alzheimers disease (AD), a disease that causes dementia, or loss of brain function. This disease affects parts of the brain that affect memory, thought, and language. Chapters in each volume focus on drug research with special emphasis on clinical trials, research on drugs in advanced stages of development and cure for Alzheimers disease and related disorders. Frontiers in Clinical Drug Research - Alzheimer Disorders will be of particular interest to readers interested in drug therapy of this specific neurodegenerative condition and related brain disorders as the series provides relevant reviews written by experts in the field of Alzheimers disease research. The eighth volume of this series features chapters covering critical discussions on new therapies for AD. The reviews in this volume include: - Novel Molecular Targets of Tauopathy; Therapeutic and Diagnostic Applications - The Therapy of Alzheimers Disease: Towards a New Generation of Drugs - Could Antibiotics Be Therapeutic Agents in Alzheimers Disease? - Use of Antipsychotics in Patients with Alzheimers Disease - Approaches Based on Cholinergic Hypothesis and Cholinesterase Inhibitors in the Treatment of Alzheimers Disease - Potential Biological Mechanisms with Prophylactic Action in Rapid Cognitive Impairment in Late-Onset Alzheimers Disease

Enzyme inhibitors play a pivotal role in pharmaceutical and nutraceutical industries. The primary understanding of the action of inhibitors helps pharmacologists during the design process for developing new therapeutic drugs. Most drugs treat various chronic and life threatening diseases owing to their specificity and the potency of enzymes which they can inhibit. Enzyme inhibitors are used to screen various levels of diseases which propel the growth of inhibitors. The potential for enzyme inhibitors in the therapeutics market is very high as the biochemical properties and classes of enzyme inhibiting products are readily available. The other broad aspect of enzyme inhibition is their application in analytical sensors. These sensors assist in monitoring various environmental factors. Understanding the mechanism of inhibition and regeneration of enzymes is a general problem of great importance for many biochemists and biotechnologists especially when using immobilized enzymes. This reference compiles applied information about enzyme inhibitors used in medicine and environmental monitoring applications. Chapters presented in this volume cover special topics including biosensors, crop improvements in agriculture, biofuel production, pesticide and heavy metal detection, and drug therapy for human diseases such as breast cancer, neurological diseases and viral infections. The collection of topics in this volume makes it an informative resource for readers at all academic levels on the applications of enzyme inhibitors in medicine and environmental sciences.

Frontiers in Clinical Drug Research Anti infectives is a book series that brings updated reviews to readers interested in learning about advances in the development of pharmaceutical agents for the treatment of infectious diseases. The scope of the book series covers a range of topics including the chemistry, pharmacology, molecular biology and biochemistry of natural and synthetic drugs employed in the treatment of infectious diseases. Reviews in this series also include research on multi drug resistance and pre-clinical / clinical findings on novel antibiotics, vaccines, antifungal agents and antitubercular agents. Frontiers in Clinical Drug Research Anti infectives is a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critically important information for developing clinical trials and devising research plans in the field of anti infective drug discovery and epidemiology. The sixth volume of this series features these interesting reviews: - Direct-acting antiviral drugs for treatment of Hepatitis C virus infection - Plant lattices as anti-infective compounds - Antimicrobial materials and devices for biomedical applications - Recent advances in the treatment of toxoplasmosis - Antimicrobial immunoglobulin prophylaxis and therapy - Targeting Magnesium Homeostasis as Potential Anti-Infective Strategy Against Mycobacteria

Frontiers in Computational Chemistry presents contemporary research on molecular modeling techniques used in drug discovery and the drug development process: computer aided molecular design, drug discovery and development, lead generation, lead optimization, database management, computer and molecular graphics, and the development of new computational methods or efficient algorithms for the simulation of chemical phenomena including analyses of biological activity. The fifth volume of this series features these six chapters: - Recent Advances and Role of Computational Chemistry in Drug Designing and Development on Viral Diseases- Molecular Modeling Applied to Design of Cysteine Protease Inhibitors A Powerful Tool for the Identification of Hit Compounds Against Neglected Tropical Diseases- Application of Systems Biology Methods in Understanding the Molecular Mechanism of Signalling Pathways in the Eukaryotic System- Implementation of the Molecular Electrostatic Potential over GPUs: Large Systems as Main Target- Molecular Electron Density Theory: A New Theoretical Outlook on Organic Chemistry- Frontier Molecular Orbital Approach to the Cycloaddition Reactions

Frontiers in Computational Chemistry presents contemporary research on molecular modeling techniques used in drug discovery and the drug development process: computer aided molecular design, drug discovery and development, lead generation, lead optimization, database management, computer and molecular graphics, and the development of new computational methods or efficient algorithms for the simulation of chemical phenomena including analyses of biological activity. The sixth volume of this series features these six different perspectives on the application of computational chemistry in rational drug design: 1. Computer-aided molecular design in computational chemistry 2. The role of ensemble conformational sampling using molecular docking & dynamics in drug discovery 3. Molecular dynamics applied to discover antiviral agents 4. Pharmacophore modeling approach in drug discovery against the tropical infectious disease malaria 5. Advances in computational network pharmacology for Traditional Chinese Medicine (TCM) research 6. Progress in electronic-structure based computational methods: from small molecules to large molecular systems of biological significance

Terpenoids are commercially important chemicals found in essential oils and other natural plant sources. They are used in solving issues that affect agricultural production, making them a key component of sustainable agronomy. Terpenoids: Recent Advances in Extraction, Biochemistry and Biotechnology provides information about the varied use of terpenoids in the control of pests, microbial diseases, ticks, and weeds. Chapters have prioritized terpenoids produced by plants, endophytic fungi, propolis, and geopropolis. The book also provides focused information about the functions of terpenoids in plants, as well as their biosynthetic pathways of production. The reference provides readers with a broad and diverse picture of the applications of terpenoids in plant safety, and creates an awareness of the possibilities for innovative biotechnological approaches for their extraction that make all the difference to agricultural production. Professionals and scholars involved in chemical technology, biotechnology and agriculture will benefit from the information provided in the book. It also serves as a comprehensive update for general readers interested in terpenoids and their current impact on the agricultural industry.

The advent of large-scale production and clinical trials of drugs developed through diverse production routes - involving viruses, microbes, plants, and animals - has increased the demand for an expanded capacity for pharmaceutical manufacturing. The production and purification of expressed proteins accounts for the bulk of the manufacturing costs for new therapeutics. Several pharmaceutical proteins have been synthesized by exploiting plant genetics allowing producers to override conventional approaches used to manufacture pharmaceuticals. The process of inserting a gene into a host organism for the purpose of harvesting a bioactive molecule for therapeutic use is known as molecular pharming. Frontiers in Molecular Pharming covers an array of topics relevant to understanding the structure, function, regulation, and mechanisms of action, biochemical significance, and usage of proteins and peptides as biomarkers, therapeutics, and vaccines for animals and humans. The contributions aim to highlight current progress in three areas, including system biology (in vivo characterization of proteins and peptides), molecular pharming for animals and molecular pharming for humans. The book gives special attention to computational biology tools, production platforms and fields (such as immunoinformatics) and applications of molecular pharming (such as veterinary therapeutics). A balance of theoretical concepts and practical applications is provided through 13 chapters. Frontiers in Molecular Pharming is an invaluable resource for students and researchers of biochemistry, molecular biology, and biotechnology. The book also serves as a springboard for understanding the process of how discoveries in protein and peptide research and its applications are coming to fruition.

Advances in Organic Synthesis is a book series devoted to the latest advances in synthetic approaches towards challenging structures. The series presents comprehensive reviews written by eminent authorities on different synthetic approaches to selected target molecules and new methods developed to achieve specific synthetic transformations or optimal product yields. Advances in Organic Synthesis is essential for all organic chemists in academia and the industry who wish to keep abreast of rapid and important developments in the field. This volume presents the following chapters:- On Water And In Water Strategies for Heterocyclic Transformations- Ionic Liquid Based Polyoxometalates as Functionalized Organic-Inorganic Hybrid Materials for Catalytic Organic Reactions- Recent Advances in the Synthesis and Bio-Applications of some Oxygen and Sulphur Containing Seven Membered Heterocyclic Compounds- Application of Nitriles on the Synthesis of 5-Membered Azaheterocycles: An Update from 2014 To 2020- The Role of Carbon-Based Solid Acid Catalysts in Organic Synthesis

Sustainable Utilization of Fungi in Agriculture and Industry covers current knowledge about different fungal microorganisms, including economically important filamentous fungi and yeasts. 22 chapters summarize information about scientific investigations and the application of fungi in the production of industrial enzymes, organic acids (citric acid, lactic acid, etc.), biofuel (ethanol and hydrogen) and bioactive compounds for sustainable processes in agriculture, bioremediation, and the industrial production of pharmaceuticals. Each chapter gives an updated and detailed account on fungal microbes and their sustainable utilization in agriculture, white biotechnology, and other valuable industrial applications. Contributions are written by experts in mycology and industrial biotechnology, presenting a broad perspective of the field in a simple, yet engaging style. Sustainable Utilization of Fungi in Agriculture and Industry is an informative reference for general readers, trainees, interested in sustainability measures in agriculture and industry. The book also serves as a resource for scholars, students and teachers involved in botany, microbiology, biotechnology and life sciences courses.

Myconanotechnology is the interface between mycology andnanotechnology. In other words, myconanotechnology represents the greensynthesis of nanoparticles using fungi. The field is recently gaining attentiondue to the simple, resource efficient, and ecofriendly nature of fungal biotechnology.Therefore, Myconanotechnology is at the core of cost-effective and sustainablesolutions for many industrial processes. This volume provides readers at all academic levels with a broadbackground on some of the fastest developing areas in myconanotechnology. It isorganised into two sections, A and B. Section A updates readers on severalcutting-edge aspects of the synthesis and characterization of nanoparticlesthrough the use of fungi. Section B describes applications of myconanotechnologyincluding: the management of bacterial and fungal diseases, pest control, amongother applications in medicine and agriculture. The breadth of topics covered inthe contents make this volume an informative resource on the field. Contributionsare written by experts in industrial biotechnology, and include extensivereferences to published studies. This book is a timely reference for researchers, teachers and students,and all readers who are interested in new developments in industrial mycologyand nanotechnology.

Edible algae, including seaweeds, are a source of functional food, dietary supplements, metabolites and bioactive compounds. Algal-based functional foods have potential health benefits, and their commercial value depends on their applications in the food and nutraceutical industries. This book covers several aspects of algal based functional foods. It informs the reader about algal cultivation techniques, environmental impact, habitat, nutraceutical potential, extraction of bioactive metabolites, functional-food composition, bio-prospection, culture-induced nutraceutical compounds, algae-based bio-packaging, algal-biorefinery, toxicity, trends and future prospects. The editors present the topics in a research-oriented format while citing scholarly references. This book is a comprehensive resource for anyone interested in the nutritional benefits and industrial utilization of algae as a sustainable food source.

Este libro se dirige fundamentalmente aquellos estudiantes universitarios que están terminando la licenciatura de Física. Puede ser igualmente útil para los licenciados que están siguiendo cursos en los que se requieren ciertos conocimientos de Fisica nuclear, asi como para quienes se inician en un trabajo de investigacion y desean familiarizarse de nuevo con los fundamentos de esta disciplina.

Drawing together the evidence of archaeology, palaeoecology, climate history and the historical record, this first environmental history of Scotland explores the interaction of human populations with the land, waters, forests and wildlife. This volume spans 450 years that saw profound transformation in Scotlands environment. It begins in the fifteenth century, when the Golden Age of the early 1200s was but a fading folk memory in a land gripped by the gathering grimness of a little ice age. Colder, wetter, stormier weather became the new normal, interspersed with brief episodes of warmer but still moist conditions, all of which brought huge challenges to a society on the knife-edge of subsistence. Viewing the religious and political upheavals of the sixteenth and seventeenth centuries against the cycles of disease and dearth that were ever-present into the later 1700s, the book explores the slow adoption and application of the ideas of Improvement and the radical disruption of Scotlands environment that ensued. Reformation, revolution and rebellion were the background noise to efforts to subsist and succeed through a hostile age, in which Scotlands environment was an adversary to be tamed, mastered and made polite. As the last, bitter decades of the little ice age were ground out in foreign wars, forced clearances and potato famines, Scotland prepared itself to embrace the Industrial Age.

The historical horse is at once material and abstract, as is the notion of the border. Borders and frontiers are not only markers delineating geographical spaces but also mental constructs: there are borders between order and disorder, between what is permitted and what is prohibited. Boundaries and liminal spaces also exist in the material, economic, political, moral, legal and religious spheres. In this volume, the contributing authors explore the theme of the liminality of the horse in all of these historical arenas, asking how does one reconcile the very different roles played by the horse in human history?

Las plantas de proceso y energía requieren, para su funcionamiento seguro y eficiente, complejos sistemas de control. Estos, a su vez, se apoyan en multitud de instrumentos, así como en redes de comunicaciones digitales industriales.Por todo ello, en los proyectos de ingenieria de tales plantas, la parte correspondiente a los sistemas de control e instrumentacion ocupa un lugar esencial. Este libro, escrito por profesionales especializados en diversos aspectos de estas tecnologias, sirve de guia para el desarrollo de tales proyectos. Su enfoque eminentemente practico no descuida los fundamentos basicos teoricos delas disciplinas involucradas. El contenido del libro puede ser util tanto a los profesionales con experiencia en estas materias como para aquellos lectoresque se estan iniciando en este apasionante campo de la ingenieria. La ediciondigital del libro ha facilitado el complementarlo con utilidades y programas de calculo de diversas tareas en los proyectos, lo que enriquece su valor comoherramienta para las labores de ingenieria y le otorga una nueva dimension practica.INDICE: INGENIERIA DE PROYECTOS DE INSTRUMENTACION.Conceptos generales. Conceptos basicos de plantas de proceso. Sistemas de control. Sistemas de transportes de señales. Proteccon de instrumentos. Norma aplicable a los proyectos. Recursos informaticos. INGENIERIA B?SICA. Anexos. ACTIVIDADES DE 1ª FASE DE PROYECTO. Conceptos generales. Otras actividades. Software complementario y corporativo. Sistemas auxiliares. Anexos. GENERALIDADES DE 2º FASE DE PROYECTO. Conceptos Generales. Documentacion de montaje de instrumentos. Actividades de obra.GESTIEN DE PROYECTOS . UTILIDADES

El objetivo de este libro es proporcionar información útil al todos cuantos intervieen en la supervisión de la contaminación general del aire en zonas urbanas y rurales, así como quienes intentan reducir a un minimo realista la emision de contaminantes del aire procedentes de procesos industriales.

El objetivo principal y último fin de este libro estriba en proporcionar un amplio y básico bagage experimental de Química orgánica con la mayor garantía de seguridad posible, mediante el método especulativo de la investigacion.Este libro esta concebido para el laboratorio que corresponde a un curso completo de Quimica organica. Este curso lo reciben dos clases diferenciadas de estudiantes, la de los que seguiran estudios de Quimica y los que se dirigen hacia una Escuela profesional (Medicina, Odontologia, etc.) o se graduaran en una Facultad de Biologia. Se tiende a considerar las metas de la educacion quimica de un modo ligeramente distinto para los que tienen la Quimica como objeto principal frente a los que cursan como disciplina complementaria.

El objeto de este libro es la descripción de los principios fundamentales, científicos y tecnológicos de los sistemas de reactores nucleares. Se dedica principal atención al proyecto de reactores y comportamiento de los mismos en relacion con el proceso de fision y radiaciones asociadas, con preferencia a otras zonas de Ingenieria que no son exclusivas de los reactores nucleares.

Química Orgânica: terpenos e rotas de síntese. Terpenos: utilidade, classificação, biossíntese, nomes, funções, reações. Rotas de síntese: síntese do ácido acetilsalicílico.